Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | UCHL1 | P09936 | 6/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 3/20 | 0.44 |
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSC | P53634 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 2/20 | 0.42 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733309 | 0.84 | NR1H2 (0.58) | HRH2HRH1DRD2ADRA1DADRA1A | |
| SCHEMBL27900241 | 0.81 | CCR8 (0.53) | DRD2CCR8MEN1CYP3A4CYP2D6 | |
| SCHEMBL4736968 | 0.81 | CCR8 (0.52) | CCR8 | |
| SCHEMBL15916163 | 0.81 | MAPT (0.65) | CCR8SFRP1 | |
| SCHEMBL4782800 | 0.80 | CTSB (0.39) | HRH2HRH1UCHL1USP30CTSB | |
| SCHEMBL4735093 | 0.79 | SFRP1 (0.47) | SFRP1 | |
| SCHEMBL4802785 | 0.79 | HTR1A (0.48) | CCR8SFRP1 | |
| SCHEMBL3811344 | 0.79 | USP30 (0.70) | UCHL1USP30CTSBCTSKCTSS | |
| SCHEMBL3806512 | 0.79 | USP30 (0.70) | UCHL1USP30CTSBCTSKCTSS | |
| SCHEMBL4735922 | 0.78 | DRD2 (0.47) | HRH2HRH1DRD2ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |