Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 5/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.34 |
| ▸ | SMO | Q99835 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14162815 | 0.87 | CHEK1 (0.37) | CHEK1CHEK2AURKAAURKBAKT1 | |
| SCHEMBL14162993 | 0.86 | CHEK1 (0.37) | CHEK1CHEK2AURKAAURKBAKT1 | |
| SCHEMBL4736887 | 0.85 | CHEK1 (0.51) | CHEK1CHEK2AKT1PPARAMAPK1 | |
| SCHEMBL4739231 | 0.85 | CHEK1 (0.50) | CHEK1CHEK2AKT1SLC34A1AKT2 | |
| SCHEMBL4736583 | 0.81 | CHEK1 (0.46) | CHEK1CHEK2AKT2 | |
| SCHEMBL4735981 | 0.80 | AURKA (0.34) | CHEK1CHEK2AURKAAURKB | |
| SCHEMBL4737095 | 0.80 | MAPK1 (0.39) | CHEK1CHEK2AKT1PPARAMAPK1 | |
| SCHEMBL4738630 | 0.80 | CHEK1 (0.38) | CHEK1CHEK2PPARAMAPK1SMO | |
| SCHEMBL4738167 | 0.75 | CHEK1 (0.35) | CHEK1CHEK2PPARAMAPK1SMO | |
| SCHEMBL4738162 | 0.75 | CHEK1 (0.35) | CHEK1CHEK2PPARAMAPK1SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |