Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 15/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 11/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14162815 | 0.87 | CHEK1 (0.37) | CHEK1CHEK2AKT1SLC34A1 | |
| SCHEMBL4735976 | 0.85 | CHEK1 (0.38) | CHEK1CHEK2AKT1AKT2SLC34A1 | |
| SCHEMBL4738157 | 0.83 | CHEK1 (0.67) | CHEK1CHEK2PRKCQMAP4K1 | |
| SCHEMBL4739449 | 0.80 | CHEK1 (0.63) | CHEK1CHEK2PRKCQMAP4K1AKT2 | |
| SCHEMBL14162993 | 0.79 | CHEK1 (0.37) | CHEK1CHEK2AKT1SLC34A1 | |
| SCHEMBL4740244 | 0.78 | CHEK1 (0.49) | CHEK1CHEK2PTPN11PRKCQMAP4K1 | |
| SCHEMBL4736887 | 0.70 | CHEK1 (0.51) | CHEK1CHEK2AKT1 | |
| SCHEMBL14162752 | 0.68 | CHEK1 (0.77) | CHEK1CHEK2PTPN11PRKCQMAP4K1 | |
| SCHEMBL21067384 | 0.67 | CHEK1 (1.00) | CHEK1CHEK2AKT2 | |
| SCHEMBL4738639 | 0.67 | CHEK1 (1.00) | CHEK1CHEK2AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |