Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 6/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 10/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.44 |
| ▸ | AKT2 | P31751 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14163061 | 0.86 | CHEK1 (0.41) | CHEK1FFAR2CHEK2AKT2LRRK2 | |
| SCHEMBL4739449 | 0.85 | CHEK1 (0.63) | CHEK1FFAR2CHEK2AKT2LRRK2 | |
| SCHEMBL4737095 | 0.82 | MAPK1 (0.39) | CHEK1CHEK2 | |
| SCHEMBL14162973 | 0.81 | CHEK1 (0.44) | CHEK1FFAR2CHEK2AKT2LRRK2 | |
| SCHEMBL4735976 | 0.81 | CHEK1 (0.38) | CHEK1CHEK2AKT2 | |
| SCHEMBL4737158 | 0.79 | JAK3 (0.54) | AKT2 | |
| SCHEMBL4736588 | 0.79 | AKT2 (0.39) | CHEK1FFAR2CHEK2AKT2 | |
| SCHEMBL4736887 | 0.78 | CHEK1 (0.51) | CHEK1CHEK2 | |
| SCHEMBL14875407 | 0.69 | CHEK1 (0.49) | CHEK1CHEK2 | |
| SCHEMBL4735212 | 0.69 | HRH4 (0.48) | CHEK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |