⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15021832 | 0.75 | — | — | |
| SCHEMBL13180943 | 0.75 | — | — | |
| SCHEMBL7418535 | 0.72 | UHRF1 (0.35) | — | |
| SCHEMBL15184555 | 0.70 | UHRF1 (0.39) | — | |
| SCHEMBL11138729 | 0.70 | CA2 (0.39) | — | |
| SCHEMBL20660792 | 0.70 | HTT (0.33) | — | |
| SCHEMBL1492552 | 0.70 | HASPIN (0.37) | — | |
| SCHEMBL10185179 | 0.70 | UHRF1 (0.34) | — | |
| SCHEMBL1163701 | 0.68 | — | — | |
| SCHEMBL4752370 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9199999-B2 | Substituted imidazopyrazines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-01 | — | — | US | disclosed |
| EP-2576560-B1 | SUBSTITUTED IMIDAZOPYRAZINES | BAYER IP GMBH (DE) | 2015-09-30 | — | — | EP | disclosed |
| US-20130217664-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2013-08-22 | — | — | US | disclosed |
| US-20130217664-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2013-08-22 | — | — | US | disclosed |
| US-20130217664-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2013-08-22 | — | — | US | disclosed |
| US-20130210815-A1 | SUBSTITUTED IMIDAZOPYRAZINES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| WO-2013117645-A1 | IMIDAZO [4, 5 -C] PYRIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2013-08-15 | — | — | WO | disclosed |
| WO-2013117645-A1 | IMIDAZO [4, 5 -C] PYRIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2013-08-15 | — | — | WO | disclosed |
| EP-2576560-A1 | SUBSTITUTED IMIDAZOPYRAZINES | Bayer Intellectual Property GmbH (DE) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011151259-A1 | SUBSTITUTED IMIDAZOPYRAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-12-08 | — | — | WO | disclosed |
| WO-2008083070-A1 | CRF1 RECEPTOR LIGANDS COMPRISING FUSED BICYCLIC HETEROARYL MOIETIES | NEUROGEN CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |