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Sugi Predict / Compounds / SCHEMBL4736407

SCHEMBL4736407

SCHEMBL4736407

O=C(c1ccc(Cl)nc1)N1CCC(NS(=O)(=O)c2ccc(-c3cccs3)cc2C(F)(F)F)CC1

nearest known ligand 0.63

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ SFRP1 Q8N474 16/20 0.63
▸ EPHX2 P34913 1/20 0.43
▸ WNT3 P56703 2/20 0.43
▸ P2RX7 Q99572 1/20 0.41
▸ DRD4 P21917 1/20 0.40
▸ HTR2A P28223 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4733575 0.89 SFRP1 (0.71) SFRP1EPHX2WNT3
SCHEMBL4735625 0.86 SFRP1 (0.66) SFRP1EPHX2WNT3
SCHEMBL4888536 0.86 SFRP1 (0.64) SFRP1EPHX2WNT3
SCHEMBL4731611 0.86 SFRP1 (0.69) SFRP1EPHX2WNT3
SCHEMBL4737870 0.86 SFRP1 (0.65) SFRP1EPHX2WNT3
SCHEMBL4784205 0.86 SFRP1 (0.63) SFRP1EPHX2WNT3
SCHEMBL4737077 0.85 SFRP1 (0.68) SFRP1EPHX2WNT3
SCHEMBL4735101 0.84 SFRP1 (0.66) SFRP1EPHX2WNT3
SCHEMBL4735165 0.84 SFRP1 (0.67) SFRP1EPHX2WNT3
SCHEMBL4731350 0.84 SFRP1 (0.61) SFRP1EPHX2WNT3P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO claimed
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO disclosed