Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 16/20 | 0.68 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | WNT3 | P56703 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731611 | 0.92 | SFRP1 (0.69) | SFRP1EPHX2WNT3 | |
| SCHEMBL4735165 | 0.90 | SFRP1 (0.67) | SFRP1EPHX2WNT3 | |
| SCHEMBL4732405 | 0.88 | SFRP1 (0.77) | SFRP1EPHX2WNT3 | |
| SCHEMBL4733575 | 0.88 | SFRP1 (0.71) | SFRP1EPHX2WNT3 | |
| SCHEMBL4733299 | 0.88 | SFRP1 (0.64) | SFRP1EPHX2 | |
| SCHEMBL4734320 | 0.88 | SFRP1 (0.64) | SFRP1EPHX2WNT3 | |
| SCHEMBL4734362 | 0.88 | SFRP1 (0.64) | SFRP1EPHX2WNT3 | |
| SCHEMBL4732049 | 0.88 | SFRP1 (0.64) | SFRP1EPHX2 | |
| SCHEMBL4732579 | 0.86 | SFRP1 (0.88) | SFRP1WNT3 | |
| SCHEMBL4888536 | 0.86 | SFRP1 (0.64) | SFRP1EPHX2WNT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |