Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 11/20 | 0.63 |
| ▸ | CHEK2 | O96017 | 9/20 | 0.59 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.48 |
| ▸ | FFAR2 | O15552 | 4/20 | 0.44 |
| ▸ | AKT2 | P31751 | 3/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736583 | 0.85 | CHEK1 (0.46) | CHEK1CHEK2PRKCQMAP4K1FFAR2 | |
| SCHEMBL14162973 | 0.82 | CHEK1 (0.44) | CHEK1CHEK2FFAR2AKT2LRRK2 | |
| SCHEMBL4740244 | 0.81 | CHEK1 (0.49) | CHEK1CHEK2PRKCQMAP4K1 | |
| SCHEMBL4739231 | 0.80 | CHEK1 (0.50) | CHEK1CHEK2PRKCQMAP4K1AKT2 | |
| SCHEMBL14163061 | 0.79 | CHEK1 (0.41) | CHEK1CHEK2FFAR2AKT2LRRK2 | |
| SCHEMBL21788682 | 0.77 | CHEK1 (0.70) | CHEK1CHEK2PRKCQMAP4K1LRRK2 | |
| SCHEMBL3916263 | 0.76 | AKT2 (0.59) | CHEK1CHEK2AKT2 | |
| SCHEMBL4736588 | 0.76 | AKT2 (0.39) | CHEK1CHEK2FFAR2AKT2 | |
| SCHEMBL4738157 | 0.76 | CHEK1 (0.67) | CHEK1CHEK2PRKCQMAP4K1FFAR2 | |
| SCHEMBL4738154 | 0.75 | CHEK1 (0.64) | CHEK1CHEK2AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |