Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | KDM1A | O60341 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2584901 | 0.98 | POLB (0.58) | POLBKDM1AMAOAMAOBHRH3 | |
| SCHEMBL31172011 | 0.93 | KDM1A (0.57) | POLBKDM1AMAOAMAOBHRH3 | |
| SCHEMBL3217424 | 0.93 | KDM1A (0.57) | POLBKDM1AMAOAMAOBHRH3 | |
| SCHEMBL3985988 | 0.79 | KDM1A (0.48) | KDM1AMAOAMAOBALDH1A1KDM4E | |
| SCHEMBL26944372 | 0.79 | HRH3 (0.57) | POLBHRH3ALDH1A1KDM4EPKM | |
| SCHEMBL5047960 | 0.78 | TRPA1 (0.48) | KDM1AMAOAMAOBALDH1A1KDM4E | |
| SCHEMBL11112228 | 0.77 | POLB (0.96) | POLBHRH3ALDH1A1KDM4EPKM | |
| SCHEMBL5048916 | 0.76 | HDAC6 (0.50) | KDM1AMAOAMAOBALDH1A1KDM4E | |
| SCHEMBL10953965 | 0.76 | HRH3 (0.88) | POLBHRH3ALDH1A1KDM4EPKM | |
| SCHEMBL5863714 | 0.75 | POLB (0.93) | POLBHRH3CXCR4GLAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |