Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.59 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.59 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739899 | 0.91 | AKR1C3 (0.60) | AKR1C3EIF2AK3AKR1C1HDAC3HDAC4 | |
| SCHEMBL4739818 | 0.91 | AKR1C3 (0.60) | AKR1C3EIF2AK3AKR1C1HDAC3HDAC4 | |
| SCHEMBL4737612 | 0.87 | LMNA (0.50) | AKR1C3AKR1C1HDAC3HDAC4HDAC1 | |
| SCHEMBL4736646 | 0.84 | AKR1C3 (0.52) | AKR1C3EIF2AK3AKR1C1HDAC3HDAC4 | |
| SCHEMBL4737423 | 0.83 | CYP3A4 (0.65) | LMNAHTTGAANPSR1MEN1 | |
| SCHEMBL4736821 | 0.82 | HDAC3 (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4741684 | 0.81 | ALDH1A1 (0.49) | LMNAMEN1KMT2APKM | |
| SCHEMBL4736785 | 0.81 | HDAC3 (0.51) | AKR1C3AKR1C1HDAC3HDAC4HDAC1 | |
| SCHEMBL4782857 | 0.79 | POLB (0.47) | AKR1C3EIF2AK3AKR1C1HDAC3HDAC4 | |
| SCHEMBL12939736 | 0.79 | AKR1C3 (0.63) | AKR1C3EIF2AK3AKR1C1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |