Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.60 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.60 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739818 | 1.00 | AKR1C3 (0.60) | AKR1C3EIF2AK3MCOLN3TSHRAKR1C1 | |
| SCHEMBL4736644 | 0.91 | AKR1C3 (0.59) | AKR1C3EIF2AK3MCOLN3TSHRAKR1C1 | |
| SCHEMBL4736709 | 0.87 | LMNA (0.57) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL4737593 | 0.87 | LMNA (0.57) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL4782857 | 0.85 | POLB (0.47) | AKR1C3EIF2AK3MCOLN3TSHRAKR1C1 | |
| SCHEMBL4736646 | 0.85 | AKR1C3 (0.52) | AKR1C3EIF2AK3MCOLN3TSHRAKR1C1 | |
| SCHEMBL4740459 | 0.84 | ALDH1A1 (0.51) | TSHRMEN1KMT2AMAPTLMNA | |
| SCHEMBL4741097 | 0.84 | ALDH1A1 (0.51) | TSHRMEN1KMT2AMAPTLMNA | |
| SCHEMBL4740191 | 0.83 | ALDH1A1 (0.55) | AKR1C3MEN1KMT2AMAPTLMNA | |
| SCHEMBL4738253 | 0.83 | MEN1 (0.57) | TSHRMEN1KMT2AHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |