Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787503 | 0.78 | PTGS2 (0.42) | TYMSKDM4EADORA2AADORA1HRH1 | |
| SCHEMBL4741269 | 0.74 | ADORA1 (0.45) | KDM4ECCNA2CDK2ADORA1HRH1 | |
| SCHEMBL4839488 | 0.72 | KDM4E (0.57) | KDM4EADORA2AADORA1ALDH1A1LMNA | |
| SCHEMBL17279668 | 0.69 | TYMS (0.41) | TYMSHRH1HRH4ALDH1A1TDP1 | |
| SCHEMBL4841960 | 0.67 | KDM4E (0.51) | KDM4EALDH1A1LMNATDP1NPC1 | |
| SCHEMBL8326420 | 0.66 | CCNA2 (0.67) | CCNA2CDK2 | |
| SCHEMBL4739911 | 0.66 | TYMS (0.52) | TYMSADORA2AADORA1 | |
| SCHEMBL7513198 | 0.65 | KDM4E (0.59) | KDM4ECCNA2CDK2ALDH1A1LMNA | |
| SCHEMBL25603965 | 0.65 | NPSR1 (0.63) | KDM4EALDH1A1LMNAHPGDNPC1 | |
| SCHEMBL10812119 | 0.64 | NPSR1 (0.68) | KDM4EADORA2AADORA1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |