SCHEMBL4741269

SCHEMBL4741269

OCCCNc1nc2c(c(-c3ccc(Cl)cc3)n1)-c1ccccc1CC2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 3/20 0.45
SMN1; SMN2 Q16637 4/20 0.45
HRH1 P35367 2/20 0.42
HRH4 Q9H3N8 2/20 0.42
ALDH1A1 P00352 4/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
KMT2A Q03164 3/20 0.41
MEN1 O00255 2/20 0.41
KDM4E B2RXH2 5/20 0.40
HPGD P15428 3/20 0.40
ATM Q13315 1/20 0.40
LMNA P02545 3/20 0.40
MAPT P10636 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
CCNA2 P20248 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4736797 0.74 TYMS (0.43) ADORA1SMN1; SMN2HRH1HRH4ALDH1A1
SCHEMBL2320673 0.70 SMN1; SMN2 (0.57) ADORA1SMN1; SMN2ALDH1A1L3MBTL1KMT2A
SCHEMBL4787503 0.70 PTGS2 (0.42) ADORA1HRH1HRH4ALDH1A1KDM4E
SCHEMBL21641647 0.67 ALDH1A1 (0.86) ADORA1SMN1; SMN2ALDH1A1L3MBTL1KMT2A
SCHEMBL17279668 0.63 TYMS (0.41) SMN1; SMN2HRH1HRH4ALDH1A1L3MBTL1
SCHEMBL14148144 0.63 CCNA2 (0.41) ADORA1HRH1HRH4KMT2AMEN1
SCHEMBL14148423 0.62 CCNA2 (0.47) ADORA1MAPTCCNA2CDK2GLA
SCHEMBL2324314 0.62 ALDH1A1 (0.56) ADORA1SMN1; SMN2ALDH1A1L3MBTL1KMT2A
SCHEMBL4739911 0.61 TYMS (0.52) ADORA1
SCHEMBL14214556 0.60 KCNH3 (0.52) ADORA1SMN1; SMN2ALDH1A1L3MBTL1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008086158-A1 BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2008-07-17 WO disclosed