Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 4/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.43 |
| ▸ | CTRC | Q99895 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11573648 | 0.91 | RHEB (0.56) | RHEBPTGDR2POLBBCL2L1TSHR | |
| SCHEMBL8533536 | 0.90 | RHEB (0.47) | RHEBTSHRAGBL2MEN1KMT2A | |
| SCHEMBL10597129 | 0.85 | ALDH1A1 (0.47) | RHEBPOLBAGBL2MEN1KMT2A | |
| SCHEMBL11156793 | 0.84 | ALDH1A1 (0.44) | RHEBPOLBSMN1; SMN2AGBL2MEN1 | |
| SCHEMBL11158594 | 0.84 | MCL1 (0.46) | RHEBPTGDR2SMN1; SMN2AGBL2MEN1 | |
| SCHEMBL4732967 | 0.84 | AGBL2 (0.62) | RHEBPOLBAGBL2MEN1KMT2A | |
| SCHEMBL10991622 | 0.83 | TSHR (0.50) | RHEBPOLBBCL2L1TSHRCASP1 | |
| SCHEMBL11758069 | 0.81 | RHEB (0.47) | RHEBPTGDR2POLBBCL2L1TSHR | |
| SCHEMBL11758969 | 0.81 | RHEB (0.52) | RHEBPTGDR2POLBBCL2L1TSHR | |
| SCHEMBL11161521 | 0.81 | MMP2 (0.44) | SMN1; SMN2AGBL2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |