Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 14/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 14/20 | 0.39 |
| ▸ | TYMS | P04818 | 2/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787389 | 0.91 | ADORA2A (0.39) | ADORA2AADORA1TYMS | |
| SCHEMBL4740441 | 0.85 | MEN1 (0.39) | ADORA2AADORA1 | |
| SCHEMBL4787508 | 0.84 | PIK3CD (0.44) | — | |
| SCHEMBL4740440 | 0.80 | TYMS (0.41) | ADORA2AADORA1TYMSPIKFYVE | |
| SCHEMBL4787518 | 0.80 | CCR2 (0.41) | — | |
| SCHEMBL4736837 | 0.80 | TYMS (0.38) | ADORA2AADORA1TYMSPIKFYVE | |
| SCHEMBL4737447 | 0.80 | TYMS (0.38) | ADORA2AADORA1TYMS | |
| SCHEMBL4740239 | 0.79 | PIK3CA (0.45) | — | |
| SCHEMBL4739014 | 0.79 | PI4KA (0.42) | — | |
| SCHEMBL14148281 | 0.78 | PIK3CA (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |