Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 18/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 18/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737411 | 0.91 | ADORA2A (0.39) | ADORA2AADORA1TYMS | |
| SCHEMBL4740757 | 0.87 | PIK3CD (0.39) | ADORA2AADORA1TYMS | |
| SCHEMBL4737408 | 0.81 | ADORA2A (0.40) | ADORA2AADORA1 | |
| SCHEMBL14148131 | 0.81 | TYMS (0.38) | ADORA2AADORA1TYMS | |
| SCHEMBL4739040 | 0.81 | PIK3CD (0.35) | ADORA2AADORA1TYMS | |
| SCHEMBL14148284 | 0.81 | ADORA1 (0.34) | ADORA2AADORA1TYMS | |
| SCHEMBL4740441 | 0.81 | MEN1 (0.39) | ADORA2AADORA1 | |
| SCHEMBL4739014 | 0.81 | PI4KA (0.42) | — | |
| SCHEMBL4741246 | 0.79 | TYMS (0.42) | ADORA2AADORA1TYMS | |
| SCHEMBL4736835 | 0.78 | CCNT1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |