Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 15/20 | 0.46 |
| ▸ | TYK2 | P29597 | 4/20 | 0.43 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.39 |
| ▸ | CDC7 | O00311 | 3/20 | 0.35 |
| ▸ | PLK4 | O00444 | 3/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.35 |
| ▸ | CDK1 | P06493 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | MARK3 | P27448 | 3/20 | 0.35 |
| ▸ | CLK2 | P49760 | 3/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787500 | 0.79 | TYMS (0.50) | TYMS | |
| SCHEMBL4739911 | 0.79 | TYMS (0.52) | TYMS | |
| SCHEMBL8261591 | 0.75 | TYMS (0.59) | TYMS | |
| SCHEMBL14148121 | 0.73 | TYMS (0.63) | TYMS | |
| Trifluoroacetic Acid SCHEMBL4742391 | 0.71 | TYMS (0.45) | TYMS | |
| SCHEMBL14148437 | 0.71 | TYMS (0.56) | TYMSMAP3K14CDK2 | |
| SCHEMBL4737438 | 0.69 | TYMS (0.47) | TYMSMAP3K14KDRCSNK1D | |
| SCHEMBL482445 | 0.68 | JAK2 (0.67) | JAK2TYK2JAK3JAK1PDPK1 | |
| SCHEMBL4737419 | 0.67 | MAP3K11 (0.38) | KDRCSNK1D | |
| SCHEMBL4740440 | 0.65 | TYMS (0.41) | TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |