Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737593 | 0.90 | LMNA (0.57) | LMNASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL4736709 | 0.90 | LMNA (0.57) | LMNASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL4739749 | 0.89 | CYP3A4 (0.63) | LMNASMN1; SMN2TDP1ALDH1A1KMT2A | |
| SCHEMBL4738988 | 0.89 | SMN1; SMN2 (0.53) | LMNASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL4737612 | 0.89 | LMNA (0.50) | LMNASMN1; SMN2ALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL4785702 | 0.88 | MAPK1 (0.52) | LMNASMN1; SMN2KDM4EMAPK1TDP1 | |
| SCHEMBL4738276 | 0.88 | CYP2C19 (0.52) | LMNASMN1; SMN2TDP1ALDH1A1KMT2A | |
| SCHEMBL4740138 | 0.87 | L3MBTL1 (0.46) | LMNASMN1; SMN2KDM4EMAPK1TDP1 | |
| SCHEMBL4808038 | 0.87 | MAPT (0.48) | LMNASMN1; SMN2KDM4EMAPK1ALDH1A1 | |
| SCHEMBL4737374 | 0.87 | L3MBTL1 (0.55) | LMNASMN1; SMN2KDM4EMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |