Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736709 | 1.00 | LMNA (0.57) | LMNASMN1; SMN2CYP2C19CYP3A4DPP4 | |
| SCHEMBL4738276 | 0.91 | CYP2C19 (0.52) | LMNASMN1; SMN2CYP2C19CYP3A4DPP4 | |
| SCHEMBL4741627 | 0.90 | CYP2C19 (0.59) | LMNASMN1; SMN2CYP2C19CYP3A4DPP4 | |
| SCHEMBL4738286 | 0.90 | LMNA (0.55) | LMNASMN1; SMN2CYP2C19CYP3A4DPP4 | |
| SCHEMBL4737612 | 0.89 | LMNA (0.50) | LMNASMN1; SMN2CYP2C19CYP3A4DPP4 | |
| SCHEMBL4740136 | 0.89 | USP5 (0.53) | LMNASMN1; SMN2CYP2C19CYP3A4DPP4 | |
| SCHEMBL4736640 | 0.89 | AKR1C3 (0.55) | LMNASMN1; SMN2CYP2C19DPP4ALDH1A1 | |
| SCHEMBL4736675 | 0.89 | MEN1 (0.54) | LMNASMN1; SMN2CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL4736676 | 0.88 | CYP3A4 (0.51) | LMNASMN1; SMN2CYP2C19CYP3A4ALDH1A1 | |
| SCHEMBL4738964 | 0.88 | POLB (0.51) | LMNASMN1; SMN2CYP2C19CYP3A4DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |