Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 7/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 7/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 7/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738751 | 0.78 | ALDH1A1 (0.53) | GUSBALDH1A1NPC1RAB9APOLB | |
| SCHEMBL24188144 | 0.69 | GUSB (0.47) | GUSBALDH1A1NPC1RAB9APOLB | |
| SCHEMBL31288988 | 0.68 | ALDH1A1 (0.49) | GUSBALDH1A1NPC1RAB9APOLB | |
| SCHEMBL8623118 | 0.68 | PTGES (0.63) | GUSBALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL24187953 | 0.65 | PDCD1 (0.62) | GUSBALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24188247 | 0.65 | PDCD1 (0.49) | GUSBALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23849970 | 0.64 | KDR (0.48) | — | |
| SCHEMBL10464 | 0.63 | MAPT (0.46) | ALDH1A1NPC1RAB9APOLBMAPT | |
| SCHEMBL801934 | 0.62 | GUSB (0.59) | GUSBALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL28365313 | 0.62 | IDO1 (0.74) | GUSBALDH1A1NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |