Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 16/20 | 0.56 |
| ▸ | PPARD | Q03181 | 9/20 | 0.54 |
| ▸ | PPARG | P37231 | 4/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14146843 | 1.00 | PPARA (0.56) | PPARAPPARDPPARGKCNH2MAPT | |
| SCHEMBL4738834 | 1.00 | PPARA (0.56) | PPARAPPARDPPARGKCNH2MAPT | |
| SCHEMBL14146505 | 0.90 | ALDH1A1 (0.47) | PPARAPPARDPPARGKCNH2MAPT | |
| SCHEMBL4739589 | 0.85 | ALDH1A1 (0.57) | PPARAPPARDPPARGMAPTALDH1A1 | |
| SCHEMBL4739592 | 0.85 | ALDH1A1 (0.57) | PPARAPPARDPPARGMAPTALDH1A1 | |
| SCHEMBL12463781 | 0.80 | PPARA (0.72) | PPARAPPARDPPARGKCNH2 | |
| SCHEMBL4737307 | 0.80 | PPARA (0.54) | PPARAPPARDPPARGMAPTALDH1A1 | |
| SCHEMBL4737309 | 0.80 | PPARA (0.54) | PPARAPPARDPPARGMAPTALDH1A1 | |
| SCHEMBL4740729 | 0.78 | MAPT (0.62) | PPARAPPARDPPARGMAPTALDH1A1 | |
| SCHEMBL4740731 | 0.78 | MAPT (0.62) | PPARAPPARDPPARGMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087367-A2 | SUBSTITUTED (PHENYLTHIAZOLYL)-PHENYL-PROPAN-1-ONE AND (PHENYLOXAZODYL)-PHENYL-PROPAN-1-ONE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087367-A2 | SUBSTITUTED (PHENYLTHIAZOLYL)-PHENYL-PROPAN-1-ONE AND (PHENYLOXAZODYL)-PHENYL-PROPAN-1-ONE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | disclosed |