Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 14/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 11/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737095 | 0.84 | MAPK1 (0.39) | CHEK1CHEK2NUDT1 | |
| SCHEMBL4739189 | 0.82 | CYP1A2 (0.44) | CHEK1CHEK2NUDT1 | |
| SCHEMBL4739449 | 0.81 | CHEK1 (0.63) | CHEK1CHEK2PRKCQMAP4K1 | |
| SCHEMBL4739231 | 0.78 | CHEK1 (0.50) | CHEK1CHEK2PTPN11PRKCQMAP4K1 | |
| SCHEMBL4738157 | 0.76 | CHEK1 (0.67) | CHEK1CHEK2PRKCQMAP4K1 | |
| SCHEMBL4735195 | 0.76 | CHEK1 (0.64) | CHEK1CHEK2NUDT1 | |
| SCHEMBL29845160 | 0.72 | ROCK1 (0.45) | — | |
| SCHEMBL26051217 | 0.69 | CHEK1 (0.44) | CHEK1CHEK2PTPN11 | |
| SCHEMBL26047166 | 0.69 | CHEK1 (0.44) | CHEK1CHEK2PTPN11 | |
| SCHEMBL14162973 | 0.68 | CHEK1 (0.44) | CHEK1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |