Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.46 |
| ▸ | BUB1 | O43683 | 1/20 | 0.45 |
| ▸ | PRKACG | P22612 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.45 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4800075 | 0.85 | MAPK14 (0.65) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL4738292 | 0.85 | MAPK14 (0.65) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL4680753 | 0.79 | MAPK14 (0.46) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL2214625 | 0.79 | MAPK14 (0.40) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL2216170 | 0.77 | KDM4E (0.39) | MAPK14CYP2C9MAPK11HPGDSNTRK1 | |
| SCHEMBL2213762 | 0.75 | MAPK1 (0.44) | — | |
| SCHEMBL2214850 | 0.75 | MAPK14 (0.46) | MAPK14HPGDSLCKKCNQ3KCNQ2 | |
| SCHEMBL14403123 | 0.75 | P4HA1 (0.49) | MAPK14CYP2C9MAPK11BUB1PRKACG | |
| SCHEMBL14161063 | 0.74 | MAPK14 (0.43) | MAPK14HPGDSLCKKCNQ3KCNQ2 | |
| SCHEMBL4035180 | 0.74 | MAPK14 (0.56) | MAPK14HPGDSLCKKCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071665-A1 | A NICOTINAMIDE DERIVATIVE USEFUL AS P38 KINASE INHIBITOR | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-19 | — | — | WO | disclosed |