Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.52 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.52 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.52 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.52 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214850 | 0.81 | MAPK14 (0.46) | MAPK14HDAC1HDAC6KCNQ3KCNQ2 | |
| SCHEMBL3767339 | 0.80 | RAB9A (0.51) | MAPK14HDAC1HDAC6LCKALDH1A1 | |
| SCHEMBL14161063 | 0.80 | MAPK14 (0.43) | MAPK14HDAC1HDAC6KCNQ3KCNQ2 | |
| SCHEMBL3892152 | 0.79 | HPGDS (0.49) | MAPK14LCKALDH1A1SMN1; SMN2HPGDS | |
| SCHEMBL379866 | 0.77 | MAPK14 (0.46) | MAPK14LCKALDH1A1SMN1; SMN2HPGDS | |
| SCHEMBL14938017 | 0.76 | OXTR (0.57) | SMN1; SMN2HPGDSKMT2A | |
| SCHEMBL1504614 | 0.76 | MAPK14 (0.58) | MAPK14HDAC1HDAC6LCKALDH1A1 | |
| SCHEMBL13213725 | 0.76 | POLB (0.50) | MAPK14LCKSMN1; SMN2HPGDSKMT2A | |
| SCHEMBL396727 | 0.75 | POLB (0.53) | MAPK14HPGDSMAPK8MAPK10KMT2A | |
| SCHEMBL14699724 | 0.74 | KMT2A (0.54) | MAPK14LCKALDH1A1SMN1; SMN2HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086973-A2 | IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF | Amgen Inc., (US) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008045393-A2 | IMIDAZO- AND TRIAZOLO-PYRIDINE COMPOUNDS AND METHODS OF USE THEROF | AMGEN INC. (US) | 2008-04-17 | — | — | WO | disclosed |