Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739594 | 1.00 | PPARD (0.41) | PPARDKDM4EIKBKBALDH1A1LMNA | |
| SCHEMBL4740490 | 0.78 | ALDH1A1 (0.52) | PPARDKDM4EALDH1A1LMNAPPARG | |
| SCHEMBL4740506 | 0.78 | ALDH1A1 (0.52) | PPARDKDM4EALDH1A1LMNAPPARG | |
| SCHEMBL4739607 | 0.77 | PPARD (0.44) | PPARDKDM4EIKBKBALDH1A1LMNA | |
| SCHEMBL2738381 | 0.76 | MAOA (0.46) | CYP1A1CYP1B1DPP4MAOAMAOB | |
| SCHEMBL219196 | 0.76 | MAOA (0.46) | CYP1A1CYP1B1DPP4MAOAMAOB | |
| SCHEMBL4737441 | 0.75 | CYP1A1 (0.58) | CYP1A1CYP1B1DPP4MAOB | |
| SCHEMBL4737444 | 0.75 | CYP1A1 (0.58) | CYP1A1CYP1B1DPP4MAOB | |
| SCHEMBL4739626 | 0.73 | IKBKB (0.58) | PPARDKDM4EIKBKBALDH1A1LMNA | |
| SCHEMBL4737346 | 0.72 | MAPT (0.41) | PPARDKDM4EALDH1A1LMNAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087367-A2 | SUBSTITUTED (PHENYLTHIAZOLYL)-PHENYL-PROPAN-1-ONE AND (PHENYLOXAZODYL)-PHENYL-PROPAN-1-ONE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008087367-A2 | SUBSTITUTED (PHENYLTHIAZOLYL)-PHENYL-PROPAN-1-ONE AND (PHENYLOXAZODYL)-PHENYL-PROPAN-1-ONE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | disclosed |