Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.63 |
| ▸ | MITF | O75030 | 1/20 | 0.61 |
| ▸ | SNCA | P37840 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | NOS1 | P29475 | 1/20 | 0.54 |
| ▸ | NOS2 | P35228 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24891741 | 0.92 | MEN1 (0.63) | RAB9ANPC1MEN1KMT2ALMNA | |
| SCHEMBL4170179 | 0.87 | PTPN1 (0.67) | PTPN1MITFSNCARAB9ANPC1 | |
| SCHEMBL15651884 | 0.87 | POLB (0.73) | SNCARAB9ANPC1MEN1KMT2A | |
| SCHEMBL8867655 | 0.86 | PTPN1 (0.65) | PTPN1MITFSNCARAB9ANPC1 | |
| SCHEMBL8867653 | 0.86 | MITF (0.68) | PTPN1MITFSNCARAB9ANPC1 | |
| SCHEMBL24670336 | 0.86 | TRPV1 (0.57) | RAB9ANPC1MEN1KMT2ALMNA | |
| SCHEMBL24667832 | 0.84 | TRPV1 (0.56) | RAB9ANPC1MEN1KMT2ALMNA | |
| SCHEMBL12310177 | 0.84 | RAB9A (0.73) | PTPN1MITFRAB9ANPC1MEN1 | |
| SCHEMBL8185226 | 0.84 | MEN1 (0.62) | PTPN1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL9236055 | 0.83 | NR1H4 (0.70) | MEN1KMT2ALMNAPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086462-A2 | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS | WYETH (US) | 2008-07-17 | — | — | WO | disclosed |