Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.55 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736814 | 0.91 | TSHR (0.47) | HSD11B1FAAHDPP4TP53MAPT | |
| SCHEMBL4736653 | 0.88 | HSD11B1 (0.55) | HSD11B1TP53EPHX2 | |
| SCHEMBL4736614 | 0.84 | HSD11B1 (0.66) | HSD11B1MEN1KMT2AEPHX2SMN1; SMN2 | |
| SCHEMBL4786375 | 0.84 | HSD11B1 (0.62) | HSD11B1MEN1KMT2ALMNA | |
| SCHEMBL4782830 | 0.84 | HSD11B1 (0.62) | HSD11B1MEN1KMT2ALMNA | |
| SCHEMBL4736702 | 0.83 | HSD11B1 (0.58) | HSD11B1TP53MAPTL3MBTL1LMNA | |
| SCHEMBL4912062 | 0.83 | HSD11B1 (0.54) | HSD11B1MAPTMEN1KMT2AUSP2 | |
| SCHEMBL4739901 | 0.82 | HSD11B1 (0.61) | HSD11B1TP53MAPTMEN1KMT2A | |
| SCHEMBL4740379 | 0.81 | HSD11B1 (0.56) | HSD11B1MEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL4738968 | 0.81 | HSD11B1 (0.58) | HSD11B1TP53MAPTKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |