Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 11/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782830 | 1.00 | HSD11B1 (0.62) | HSD11B1TSHRLMNAALDH1A1MEN1 | |
| SCHEMBL4740379 | 0.91 | HSD11B1 (0.56) | HSD11B1TSHRLMNAALDH1A1MEN1 | |
| SCHEMBL4736702 | 0.91 | HSD11B1 (0.58) | HSD11B1TSHRLMNAALDH1A1RAB9A | |
| SCHEMBL4738968 | 0.91 | HSD11B1 (0.58) | HSD11B1TSHRALDH1A1KMT2A | |
| SCHEMBL4736700 | 0.90 | TSHR (0.58) | HSD11B1TSHRLMNAALDH1A1KMT2A | |
| SCHEMBL4738255 | 0.90 | TSHR (0.58) | HSD11B1TSHRLMNAALDH1A1KMT2A | |
| SCHEMBL4738916 | 0.90 | HDAC3 (0.52) | HSD11B1TSHRLMNAATAD2 | |
| SCHEMBL4739746 | 0.90 | HDAC3 (0.52) | HSD11B1TSHRLMNAATAD2 | |
| SCHEMBL4739751 | 0.89 | HSD11B1 (0.54) | HSD11B1TSHRLMNAALDH1A1MAPK1 | |
| SCHEMBL4736614 | 0.87 | HSD11B1 (0.66) | HSD11B1TSHRLMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | claimed |
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |