Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782830 | 0.87 | HSD11B1 (0.62) | HSD11B1RAB9ALMNAALDH1A1MEN1 | |
| SCHEMBL4786375 | 0.87 | HSD11B1 (0.62) | HSD11B1RAB9ALMNAALDH1A1MEN1 | |
| SCHEMBL4912062 | 0.85 | HSD11B1 (0.54) | HSD11B1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL4739901 | 0.85 | HSD11B1 (0.61) | HSD11B1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL4736653 | 0.85 | HSD11B1 (0.55) | HSD11B1EPHX2ALDH1A1POLB | |
| SCHEMBL4740132 | 0.84 | HSD11B1 (0.55) | HSD11B1EPHX2LMNASMN1; SMN2MEN1 | |
| SCHEMBL4736702 | 0.84 | HSD11B1 (0.58) | HSD11B1RAB9ALMNAALDH1A1L3MBTL1 | |
| SCHEMBL4738968 | 0.83 | HSD11B1 (0.58) | HSD11B1ALDH1A1KMT2AL3MBTL1TSHR | |
| SCHEMBL4740379 | 0.82 | HSD11B1 (0.56) | HSD11B1LMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4739751 | 0.82 | HSD11B1 (0.54) | HSD11B1LMNAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |