Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | CCR1 | P32246 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741083 | 0.99 | TSHR (0.58) | TSHRLMNAKMT2AHSD11B1CHRM1 | |
| Potassium Ion SCHEMBL4740462 | 0.97 | TSHR (0.55) | TSHRLMNAKMT2AHSD11B1CHRM1 | |
| SCHEMBL4739901 | 0.88 | HSD11B1 (0.61) | TSHRLMNAKMT2AHSD11B1MAPT | |
| SCHEMBL4736700 | 0.85 | TSHR (0.58) | TSHRLMNAKMT2AHSD11B1CHRM1 | |
| SCHEMBL4738255 | 0.85 | TSHR (0.58) | TSHRLMNAKMT2AHSD11B1CHRM1 | |
| SCHEMBL4736643 | 0.84 | TSHR (0.51) | TSHRLMNAKMT2AHSD11B1CHRM1 | |
| SCHEMBL4741087 | 0.84 | AKR1C3 (0.48) | TSHRLMNAKMT2AHSD11B1AKR1C3 | |
| SCHEMBL4739786 | 0.83 | TSHR (0.50) | TSHRLMNAKMT2AHSD11B1CHRM1 | |
| SCHEMBL4785915 | 0.82 | L3MBTL1 (0.51) | TSHRLMNAKMT2AHSD11B1CHRM1 | |
| SCHEMBL4740430 | 0.81 | TSHR (0.48) | TSHRLMNAKMT2AHSD11B1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |