Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739616 | 0.88 | ALDH1A1 (0.55) | ALDH1A1MAPTKMT2AMEN1PPARA | |
| SCHEMBL4739679 | 0.84 | PPARA (0.57) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL14146335 | 0.84 | KMT2A (0.43) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL4739681 | 0.81 | MAPT (0.61) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL217561 | 0.79 | HDAC6 (0.43) | MAPTKMT2AMEN1 | |
| SCHEMBL4740738 | 0.79 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL4740739 | 0.79 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL4738885 | 0.78 | MAPT (0.49) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL4741590 | 0.77 | MAPT (0.50) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL4738817 | 0.77 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087367-A2 | SUBSTITUTED (PHENYLTHIAZOLYL)-PHENYL-PROPAN-1-ONE AND (PHENYLOXAZODYL)-PHENYL-PROPAN-1-ONE DERIVATIVES, PREPARATIONS AND USES OF SAME | GENFIT (FR) | 2008-07-24 | — | — | WO | disclosed |