SCHEMBL474145

SCHEMBL474145

CC(C)=CCC/C(C)=C/CN1CCCC1=O

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.43
ALOX15 P16050 3/20 0.41
MEN1 O00255 2/20 0.41
CYP3A4 P08684 2/20 0.41
PIK3CD O00329 1/20 0.40
ALDH1A1 P00352 3/20 0.40
MAPT P10636 2/20 0.40
UGT1A1 P22309 1/20 0.40
TSHR P16473 1/20 0.39
ALOX5 P09917 2/20 0.39
SQLE Q14534 1/20 0.39
MAOB P27338 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10706181 0.98 KMT2A (0.46) KMT2AALOX15MEN1CYP3A4ALDH1A1
SCHEMBL118427 0.98 KMT2A (0.46) KMT2AALOX15MEN1CYP3A4ALDH1A1
SCHEMBL120741 0.95 KMT2A (0.42) KMT2AALOX15MEN1CYP3A4ALDH1A1
SCHEMBL120742 0.95 KMT2A (0.42) KMT2AALOX15MEN1CYP3A4ALDH1A1
SCHEMBL121342 0.94 KMT2A (0.41) KMT2AALOX15MEN1CYP3A4ALDH1A1
SCHEMBL5857342 0.94 KMT2A (0.44) KMT2AALOX15MEN1CYP3A4ALDH1A1
SCHEMBL5857338 0.94 KMT2A (0.44) KMT2AALOX15MEN1CYP3A4ALDH1A1
SCHEMBL121994 0.94 KMT2A (0.41) KMT2AALOX15MEN1CYP3A4ALDH1A1
SCHEMBL123153 0.93 KMT2A (0.43) KMT2AALOX15MEN1CYP3A4ALDH1A1
SCHEMBL123154 0.93 KMT2A (0.43) KMT2AALOX15MEN1CYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090215888-A1 TOPICAL NAIL FORMULATION NUVO RESEARCH INC. (CA) 2009-08-27 US claimed
EP-1909772-A1 TRANSDERMAL DRUG DELIVERY FORMULATION Nuvo Research Inc. (CA) 2008-04-16 EP claimed
US-20070269379-A1 Penetration Enhancer Combinations for Transdermal Delivery REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE 2007-11-22 US claimed
WO-2007098591-A2 TOPICAL NAIL FORMULATION NUVO RESEARCH INC. (CA) 2007-09-07 WO claimed
WO-2007016766-A1 TRANSDERMAL DRUG DELIVERY FORMULATION NUVO RESEARCH INC. (CA) 2007-02-15 WO claimed
WO-2005009510-A2 PENETRATION ENHANCER COMBINATIONS FOR TRANSDERMAL DELIVERY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-02-03 WO claimed
EP-3324930-B1 DELIVERY OF DRUG NANOPARTICLES AND METHODS OF USE THEREOF DFB SORIA LLC (US) 2025-09-17 EP disclosed
US-12329858-B2 Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer CRITITECH, INC. (US) 2025-06-17 US disclosed
US-20240252441-A1 Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer CRITITECH, INC. 2024-08-01 US disclosed
US-11918691-B2 Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer CRITITECH, INC. (US) 2024-03-05 US disclosed
US-20230263731-A1 Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer CRITITECH, INC. 2023-08-24 US disclosed
EP-3595633-B1 TOPICAL THERAPY FOR THE TREATMENT OF SKIN MALIGNANCIES USING NANOPARTICLES OF TAXANES DFB SORIA LLC (US) 2023-07-05 EP disclosed
US-11633349-B2 Topical therapy for the treatment of skin malignancies using nanoparticles of taxanes DFB SORIA, LLC (US) 2023-04-25 US disclosed
WO-2007098591-A2 TOPICAL NAIL FORMULATION NUVO RESEARCH INC. (CA) 2007-09-07 WO disclosed
US-20070183936-A1 Apparatus and methods for evaluating the barrier properties of a membrane NUVO RESEARCH US, INC. 2007-08-09 US disclosed
WO-2007016766-A1 TRANSDERMAL DRUG DELIVERY FORMULATION NUVO RESEARCH INC. (CA) 2007-02-15 WO disclosed
WO-2006091297-A2 MOLECULES TO ENHANCE PERCUTANEOUS DELIVERY AND METHODS FOR DISCOVERY THEREFOR THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-08-31 WO disclosed
EP-1680223-A2 APPARATUS AND METHODS FOR EVALUATING THE BARRIER PROPERTIES OF A MEMBRANE Fqubed, Inc. (US) 2006-07-19 EP disclosed
WO-2005012549-A2 APPARATUS AND METHODS FOR EVALUATING THE BARRIER PROPERTIES OF A MEMBRANE FQUBED, INC. (US) 2005-02-10 WO disclosed
WO-2005009510-A2 PENETRATION ENHANCER COMBINATIONS FOR TRANSDERMAL DELIVERY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-02-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12329858-B2 Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer TP53, IPO5, NUP205 KMT2A 4814/4885ALOX15 2657/4885MEN1 1285/4885
US-11918691-B2 Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer ARID2, ACIN1, TP53 KMT2A 3780/4885ALOX15 3316/4885MEN1 1571/4885
US-11633349-B2 Topical therapy for the treatment of skin malignancies using nanoparticles of taxanes KRT18, TUBB3, TUBA3E KMT2A 2936/4885ALOX15 2976/4885MEN1 1701/4885
US-20230263731-A1 Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer ARID2, ACIN1, TP53 KMT2A 3780/4885ALOX15 3316/4885MEN1 1571/4885
US-20240252441-A1 Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer TP53, IPO5, NUP205 KMT2A 4814/4885ALOX15 2657/4885MEN1 1285/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.