Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 14/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | OGA | O60502 | 5/20 | 0.32 |
| ▸ | USP1 | O94782 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474160 | 0.76 | OPRD1 (0.78) | OPRD1OPRM1KCNH2USP1 | |
| Azd-7268 SCHEMBL474151 | 0.74 | OPRD1 (1.00) | OPRD1OPRM1KCNH2 | |
| Azd-7268 SCHEMBL30248100 | 0.74 | OPRD1 (1.00) | OPRD1OPRM1KCNH2 | |
| SCHEMBL12432542 | 0.63 | OPRD1 (0.72) | OPRD1OPRM1KCNH2 | |
| SCHEMBL12432534 | 0.62 | OPRD1 (0.71) | OPRD1OPRM1KCNH2 | |
| SCHEMBL474620 | 0.62 | OPRD1 (0.70) | OPRD1OPRM1KCNH2 | |
| SCHEMBL474252 | 0.61 | OPRM1 (0.62) | OPRD1OPRM1KCNH2 | |
| SCHEMBL14228324 | 0.61 | OPRD1 (0.67) | OPRD1OPRM1KCNH2 | |
| SCHEMBL474169 | 0.60 | OPRD1 (0.65) | OPRD1OPRM1KCNH2 | |
| SCHEMBL474192 | 0.60 | OPRM1 (0.64) | OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079735-B1 | N- (2 -HYDROXYETHYL) -N-METHYL- 4- (QUINOLIN- 8-YL (1- (THIAZOL-4- YLMETHYL) PIPERIDIN- 4 -YLIDENE) METHYL) BENZAMIDE, THE PROCESS OF MAKING IT AS WELL AS ITS USE FOR THE TREATMENT OF PAIN, ANXIETY AND DEPRESSION. | ASTRAZENECA AB (SE) | 2012-02-01 | — | — | EP | disclosed |
| CN-101528739-B | N- (2 -hydroxyethyl) -n-methyl- 4- (quinolin- 8-yl (1- (thiazol-4- ylmethyl) piperidin- 4 -ylidene) methyl) benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression | ASTRAZENECA AB (SE) | 2011-11-30 | — | — | CN | disclosed |
| CN-101528739-A | N- (2 -hydroxyethyl) -n-methyl- 4- (quinolin- 8-yl (1- (thiazol-4- ylmethyl) piperidin- 4 -ylidene) methyl) benzamide, the process of making it as well as its use for the treatment of pain, anxiety an | ASTRAZENECA AB (SE) | 2009-09-09 | — | — | CN | disclosed |
| EP-2079735-A1 | N- (2 -HYDROXYETHYL) -N-METHYL- 4- (QUINOLIN- 8-YL (1- (THIAZOL-4- YLMETHYL) PIPERIDIN- 4 -YLIDENE) METHYL) BENZAMIDE, THE PROCESS OF MAKING IT AS WELL AS ITS USE FOR THE TREATMENT OF PAIN, ANXIETY AND DEPRESSION. | AstraZeneca AB (SE) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008048171-A1 | N- (2 -HYDROXYETHYL) -N-METHYL- 4- (QUINOLIN- 8-YL (1- (THIAZOL-4- YLMETHYL) PIPERIDIN- 4 -YLIDENE) METHYL) BENZAMIDE, THE PROCESS OF MAKING IT AS WELL AS ITS USE FOR THE TREATMENT OF PAIN, ANXIETY AND DEPRESSION. | ASTRAZENECA AB (SE) | 2008-04-24 | — | — | WO | disclosed |