Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 8/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784797 | 0.89 | APLNR (0.48) | APLNRKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4741828 | 0.83 | APLNR (0.44) | APLNRKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4782896 | 0.83 | KMT2A (0.44) | APLNRKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4737525 | 0.79 | KMT2A (0.54) | APLNRKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4740213 | 0.79 | KMT2A (0.42) | APLNRKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4740765 | 0.76 | EGLN1 (0.42) | APLNREGFRBTK | |
| SCHEMBL17317042 | 0.76 | APLNR (0.51) | APLNRKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4784791 | 0.74 | APLNR (0.42) | APLNRKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4739124 | 0.73 | HPGD (0.43) | APLNRKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL4739975 | 0.72 | KMT2A (0.38) | APLNRKDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089051-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES: PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |