Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 7/20 | 0.60 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 6/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29689702 | 1.00 | MPL (0.60) | MPLTYRALDH1A1ALOX5RAB9A | |
| SCHEMBL1802937 | 0.88 | MPL (0.60) | MPLTYRALDH1A1ALOX5RAB9A | |
| SCHEMBL474342 | 0.82 | MPL (0.61) | MPLTYRALDH1A1ALOX5RAB9A | |
| SCHEMBL1800573 | 0.81 | MPL (0.55) | MPLALDH1A1ALOX5RAB9AHSD17B10 | |
| SCHEMBL474653 | 0.79 | MPL (0.75) | MPLTYRALDH1A1ALOX5RAB9A | |
| SCHEMBL10275635 | 0.79 | MPL (0.64) | MPLTYRALDH1A1ALOX5RAB9A | |
| SCHEMBL10087321 | 0.78 | MPL (0.56) | MPLTYRALDH1A1ALOX5RAB9A | |
| SCHEMBL10315908 | 0.78 | MPL (0.56) | MPLTYRALDH1A1ALOX5RAB9A | |
| SCHEMBL474214 | 0.78 | MPL (0.56) | MPLTYRALDH1A1ALOX5RAB9A | |
| SCHEMBL474303 | 0.75 | MPL (1.00) | MPLTYRALDH1A1ALOX5RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2708538-B1 | Process for preparing fused pyrimidine-dione derivatives, useful as as TRPA1 modulators | GLENMARK PHARMACEUTICALS SA (CH) | 2015-08-12 | — | — | EP | claimed |
| US-9000159-B2 | Fused pyrimidine-dione derivatives as TRPA1 modulators | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-07 | — | — | US | claimed |
| US-8987278-B2 | Thienopyrimidinedione derivatives as TRPA1 modulators | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-03-24 | — | — | US | claimed |
| US-20140128603-A1 | FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2014-05-08 | — | — | US | claimed |
| EP-2708538-A1 | Process for preparing fused pyrimidine-dione derivatives, useful as as TRPA1 modulators | Glenmark Pharmaceuticals S.A. (CH) | 2014-03-19 | — | — | EP | claimed |
| US-20130289054-A1 | THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-10-31 | — | — | US | claimed |
| CN-114891003-B | Novel dihydropyrimidine compound, intermediate or salt, and preparation method and application thereof | 成都施贝康生物医药科技有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-114656472-B | Pyrazolopyrimidine compound, isomer or salt, and preparation method and application thereof | 成都施贝康生物医药科技有限公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-114891003-A | Novel dihydropyrimidine compounds, intermediates or salts, and preparation method and application thereof | 成都施贝康生物医药科技有限公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-114671875-A | Novel dihydropyrimidine compound, isomer or salt, and preparation method and application thereof | 成都施贝康生物医药科技有限公司 | 2022-06-28 | — | — | CN | disclosed |
| CN-114656472-A | Pyrazolopyrimidine compound, isomer or salt, and preparation method and application thereof | 成都施贝康生物医药科技有限公司 | 2022-06-24 | — | — | CN | disclosed |
| EP-2858999-B1 | AMIDES OF 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AND THEIR SALTS | GLENMARK PHARMACEUTICALS SA (CH) | 2017-05-10 | — | — | EP | disclosed |
| EP-2858999-B1 | AMIDES OF 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AND THEIR SALTS | GLENMARK PHARMACEUTICALS SA (CH) | 2017-05-10 | — | — | EP | disclosed |
| WO-2010109328-A1 | ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010109328-A1 | ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010004390-A1 | QUINAZOLINE DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-01-14 | — | — | WO | disclosed |
| WO-2010004390-A1 | QUINAZOLINE DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-01-14 | — | — | WO | disclosed |
| US-20090325987-A1 | QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2009-12-31 | — | — | US | disclosed |
| US-20090325987-A1 | QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2009-12-31 | — | — | US | disclosed |
| US-20090325987-A1 | QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128603-A1 | FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS | TRPA1, TRPV1, TRPV2 | MPL 3331/4885TYR 1264/4885ALDH1A1 639/4885 |
| US-20130289054-A1 | THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS | TRPA1, TRPV1, TRPV6 | MPL 2776/4885TYR 948/4885ALDH1A1 475/4885 |
| US-20090325987-A1 | QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS | TRPA1, TRPV1, TRPC3 | MPL 4421/4885TYR 1094/4885ALDH1A1 871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.