Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 13/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.53 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | INSR | P06213 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4744349 | 0.84 | FGFR1 (0.56) | MAP3K11DYRK1ADYRK2DYRK1BCLK1 | |
| SCHEMBL4743683 | 0.79 | PRMT5 (0.53) | MAP3K11DYRK1ADYRK2DYRK1BCLK1 | |
| SCHEMBL4746507 | 0.78 | DYRK1A (0.56) | MAP3K11DYRK1ADYRK2DYRK1BCLK1 | |
| SCHEMBL21069142 | 0.78 | PRMT5 (0.54) | DYRK1ADYRK2DYRK1BCLK1PRMT5 | |
| SCHEMBL4744090 | 0.77 | PLCG1 (0.47) | MAP3K11DYRK1ADYRK2DYRK1BCLK1 | |
| SCHEMBL4743347 | 0.76 | PRMT5 (0.56) | MAP3K11DYRK1ADYRK2DYRK1BCLK1 | |
| SCHEMBL4200987 | 0.75 | MAPK8 (0.60) | MAP3K11DYRK1ADYRK2DYRK1BCLK1 | |
| SCHEMBL12762993 | 0.75 | MAP3K11 (0.75) | MAP3K11DYRK1ADYRK2DYRK1BCLK1 | |
| SCHEMBL723789 | 0.74 | MAP3K11 (1.00) | MAP3K11DYRK1ADYRK2DYRK1BCLK1 | |
| SCHEMBL4746489 | 0.73 | MAPK8 (0.51) | MAP3K11PRMT5WDR77LRRK2AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |