Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 1/20 | 0.47 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.42 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.42 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.42 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746434 | 0.79 | KIT (0.56) | PLCG1LRRK2PRMT5WDR77AAK1 | |
| SCHEMBL4209183 | 0.79 | CYP11B1 (0.49) | LRRK2PRMT5WDR77AAK1NTRK1 | |
| SCHEMBL4743363 | 0.77 | MAP3K11 (0.58) | MAP3K11LRRK2PRMT5WDR77AAK1 | |
| SCHEMBL4199507 | 0.74 | CAMKK2 (0.61) | LRRK2PRMT5WDR77AAK1 | |
| SCHEMBL4746448 | 0.72 | PRMT5 (0.49) | MAP3K11LRRK2PRMT5WDR77AAK1 | |
| SCHEMBL21069142 | 0.71 | PRMT5 (0.54) | LRRK2PRMT5WDR77AAK1CYP3A4 | |
| SCHEMBL4351841 | 0.71 | CHEK1 (0.58) | LRRK2PRMT5WDR77AAK1NTRK1 | |
| SCHEMBL4743347 | 0.70 | PRMT5 (0.56) | MAP3K11LRRK2PRMT5WDR77AAK1 | |
| SCHEMBL29709511 | 0.70 | ASH1L (0.50) | PIK3CDPRKCQPRKCDPIK3CBPIK3CG | |
| SCHEMBL6321495 | 0.70 | PIK3CD (0.48) | PIK3CDLRRK2PRKCQPRKCDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |