Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | ITK | Q08881 | 2/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 4/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | STK16 | O75716 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.41 |
| ▸ | STK3 | Q13188 | 1/20 | 0.41 |
| ▸ | STK11 | Q15831 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746451 | 0.89 | BTK (0.56) | BTKITKRIPK1IGF1RCDK8 | |
| SCHEMBL14069152 | 0.86 | PRMT5 (0.42) | PRMT5WDR77CLK1DYRK1ADYRK2 | |
| SCHEMBL4743370 | 0.79 | AAK1 (0.55) | PRMT5WDR77CLK1DYRK1ADYRK2 | |
| SCHEMBL14069150 | 0.77 | BTK (0.50) | BTKITKSGK1CDK8 | |
| SCHEMBL4162816 | 0.73 | CDK8 (0.45) | BTKITKAXLAAK1SGK1 | |
| SCHEMBL4743697 | 0.72 | PRMT5 (0.53) | PRMT5WDR77CLK1DYRK1ADYRK2 | |
| SCHEMBL4745695 | 0.72 | DYRK1B (0.64) | PRMT5WDR77CLK1DYRK1ADYRK2 | |
| SCHEMBL21069142 | 0.72 | PRMT5 (0.54) | PRMT5WDR77CLK1DYRK1ADYRK2 | |
| SCHEMBL4747758 | 0.72 | PRMT5 (0.55) | PRMT5WDR77CLK1DYRK1ADYRK2 | |
| SCHEMBL8254990 | 0.71 | TNIK (0.51) | PRMT5WDR77RIPK1AXLTNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |