Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.55 |
| ▸ | AXL | P30530 | 6/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
| ▸ | STK16 | O75716 | 1/20 | 0.55 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | NEK2 | P51955 | 1/20 | 0.55 |
| ▸ | STK3 | Q13188 | 1/20 | 0.55 |
| ▸ | STK11 | Q15831 | 1/20 | 0.55 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.55 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | SGK1 | O00141 | 2/20 | 0.50 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743697 | 0.82 | PRMT5 (0.53) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL4743377 | 0.79 | PRMT5 (0.46) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL8254990 | 0.78 | TNIK (0.51) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL4743685 | 0.77 | PRMT5 (0.50) | AAK1AXLTNIKSGK1CAMKK2 | |
| SCHEMBL7118403 | 0.77 | AAK1 (0.82) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL4745695 | 0.75 | DYRK1B (0.64) | TNIKCLK1DYRK1ADYRK1BNTRK1 | |
| SCHEMBL21069142 | 0.75 | PRMT5 (0.54) | AAK1AXLTNIKCLK1DYRK1A | |
| SCHEMBL8320090 | 0.74 | AXL (0.62) | AXLSTK3TNIKSGK1CAMKK2 | |
| SCHEMBL4747692 | 0.74 | TNIK (0.63) | AAK1AXLGAKSTK16PIM1 | |
| SCHEMBL7111896 | 0.74 | AAK1 (0.67) | AAK1AXLSGK1CAMKK2RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |