Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 10/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740295 | 0.92 | PTGS1 (0.40) | MAPK1MEN1KMT2AALDH1A1CYP2C19 | |
| SCHEMBL14104079 | 0.91 | CYP1A2 (0.36) | MAPK1CYP1A2CYP3A4CYP2D6MEN1 | |
| SCHEMBL4573992 | 0.91 | MAPK1 (0.44) | MAPK1CYP2C19CYP2C9MAPTPDE4A | |
| SCHEMBL11990372 | 0.90 | AR (0.39) | MAPK1CYP1A2CYP3A4CYP2D6MEN1 | |
| SCHEMBL14104167 | 0.90 | KDM4E (0.35) | MAPK1MEN1KMT2AALDH1A1CYP2C19 | |
| SCHEMBL14103888 | 0.90 | PIK3CA (0.37) | MAPK1CYP2C19CYP2C9MAPTL3MBTL1 | |
| SCHEMBL14103801 | 0.89 | PIK3CA (0.43) | MAPK1CYP1A2CYP3A4CYP2D6MEN1 | |
| SCHEMBL4740912 | 0.89 | ABCG2 (0.35) | MAPK1CYP1A2CYP3A4CYP2D6MEN1 | |
| SCHEMBL4738829 | 0.89 | NR1I3 (0.40) | MAPK1CYP1A2CYP3A4CYP2D6MEN1 | |
| SCHEMBL14103767 | 0.89 | HTT (0.43) | CYP1A2CYP3A4ALDH1A1CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092860-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | claimed |
| WO-2008092860-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |