Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 9/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743431 | 0.91 | MAPK1 (0.40) | MAPK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4740295 | 0.91 | PTGS1 (0.40) | MAPK1PRKCISCN9AABCG2CYP2C9 | |
| SCHEMBL14104167 | 0.89 | KDM4E (0.35) | MAPK1PRKCISCN9ACYP2C9CYP2C19 | |
| SCHEMBL14103888 | 0.89 | PIK3CA (0.37) | MAPK1PRKCISCN9AABCG2CYP2C9 | |
| SCHEMBL14103767 | 0.88 | HTT (0.43) | ABCG2CYP2C9CYP2C19MAPT | |
| SCHEMBL4574851 | 0.87 | PRKCI (0.38) | MAPK1PRKCISCN9ACYP2C9CYP2C19 | |
| SCHEMBL4574977 | 0.86 | MAPK1 (0.51) | MAPK1PRKCIPDE4APDE4BPDE4C | |
| SCHEMBL14104079 | 0.86 | CYP1A2 (0.36) | MAPK1PRKCISCN9AABCG2CYP2C9 | |
| SCHEMBL14095137 | 0.85 | ABCG2 (0.41) | SCN9AABCG2CYP2C9CYP2C19MAPT | |
| SCHEMBL11990372 | 0.85 | AR (0.39) | MAPK1PRKCISCN9AABCG2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | claimed |
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |
| WO-2008092862-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |