Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11990372 | 0.91 | AR (0.39) | CYP1A2CYP3A4TSHRCYP2D6ABCG2 | |
| SCHEMBL4743431 | 0.91 | MAPK1 (0.40) | CYP1A2CYP3A4TSHRCYP2D6ABCG2 | |
| SCHEMBL4738829 | 0.90 | NR1I3 (0.40) | CYP1A2CYP3A4TSHRCYP2D6ABCG2 | |
| SCHEMBL4740912 | 0.90 | ABCG2 (0.35) | CYP1A2CYP3A4TSHRCYP2D6ABCG2 | |
| SCHEMBL14103801 | 0.90 | PIK3CA (0.43) | CYP1A2CYP3A4TSHRCYP2D6ABCG2 | |
| SCHEMBL14103886 | 0.89 | ABCG2 (0.44) | CYP1A2CYP3A4TSHRCYP2D6ABCG2 | |
| SCHEMBL4740295 | 0.89 | PTGS1 (0.40) | ABCG2MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL4573992 | 0.86 | MAPK1 (0.44) | ABCG2CYP2C19CYP2C9MAPK1SCN9A | |
| SCHEMBL14103792 | 0.85 | L3MBTL1 (0.36) | CYP2C19CYP2C9SCN9APRKCIGABRG2 | |
| SCHEMBL14104167 | 0.85 | KDM4E (0.35) | MEN1KMT2ACYP2C19LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092861-A1 | BICYCLIC DERIVATIVES AS EP4 AGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-07 | — | — | WO | disclosed |