Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22395760 | 0.92 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1CCNCCDK8 | |
| SCHEMBL4739993 | 0.88 | THRB (0.54) | SMN1; SMN2THRBCKS1BSKP1SKP2 | |
| SCHEMBL4742620 | 0.88 | THRB (0.64) | THRBALDH1A1LMNAMAPT | |
| SCHEMBL4742143 | 0.84 | ALDH1A1 (0.58) | SMN1; SMN2CKS1BSKP1SKP2PTPN11 | |
| SCHEMBL4785479 | 0.80 | THRB (0.42) | SMN1; SMN2THRBCKS1BSKP1SKP2 | |
| SCHEMBL22396176 | 0.80 | MAPT (0.59) | THRBALDH1A1LMNATP53MAPT | |
| SCHEMBL4743456 | 0.80 | MAPT (0.47) | SMN1; SMN2THRBCKS1BSKP1SKP2 | |
| SCHEMBL23727334 | 0.79 | MAPT (0.52) | SMN1; SMN2CKS1BSKP1SKP2ALDH1A1 | |
| SCHEMBL30080180 | 0.79 | MAPT (0.52) | SMN1; SMN2CKS1BSKP1SKP2ALDH1A1 | |
| SCHEMBL30080182 | 0.79 | MAPT (0.52) | SMN1; SMN2CKS1BSKP1SKP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008093940-A1 | QUINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PREPARATION PROCESS FOR THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | YUNGJIN PHARMACEUTICAL CO., LTD. (KR) | 2008-08-07 | — | — | WO | disclosed |