Known targets — ChEMBL curated mechanism
POLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PRIM1PRIM2RRM1RRM2RRM2B
The experimentally established mechanism targets of Fludarabine Phosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.73 |
| ▸ | NT5E | P21589 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | IMPDH2 | P12268 | 6/20 | 0.57 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.55 |
| ▸ | P2RY11 | Q96G91 | 3/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.55 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.55 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.55 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.55 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.55 |
| ▸ | LDHA | P00338 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | FBP1 | P09467 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.55 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.55 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.55 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fludarabine Phosphate SCHEMBL5329821 | 1.00 | CA5A (0.73) | CA5ANT5ELMNAHIF1AIMPDH2 | |
| Fludarabine Phosphate SCHEMBL28198534 | 0.97 | CA5A (0.78) | CA5ANT5ELMNAHIF1AIMPDH2 | |
| Fludarabine Phosphate SCHEMBL28199095 | 0.96 | CA5A (0.77) | CA5ANT5ELMNAHIF1AIMPDH2 | |
| Fludarabine SCHEMBL726385 | 0.92 | NT5E (0.74) | CA5ANT5ELMNAHIF1AADORA1 | |
| Fludarabine Phosphate SCHEMBL28277514 | 0.91 | CA5A (0.61) | CA5ANT5ELMNAHIF1AIMPDH2 | |
| Fludarabine Phosphate SCHEMBL28136086 | 0.91 | CA5A (0.60) | CA5ANT5ELMNAHIF1AIMPDH2 | |
| Fludarabine Phosphate SCHEMBL2301453 | 0.89 | CA5A (0.93) | CA5ANT5ELMNAHIF1AIMPDH2 | |
| Fludarabine Phosphate SCHEMBL28142252 | 0.89 | CA5A (0.59) | CA5ANT5ELMNAHIF1AIMPDH2 | |
| Fludarabine Phosphate SCHEMBL23884975 | 0.86 | CA5A (1.00) | CA5ANT5ELMNAHIF1AIMPDH2 | |
| Fludarabine Phosphate SCHEMBL17541855 | 0.86 | CA5A (1.00) | CA5ANT5ELMNAHIF1AIMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776387-A1 | TRICYCLIC AMINO CONTAINING COMPOUNDS FOR TREATMENT OR PREVENTION OF SYMPTOMS ASSOCIATED WITH ENDOCRINE DYSFUNCTION | Emory University (US) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013070660-A1 | TRICYCLIC AMINO CONTAINING COMPOUNDS FOR TREATMENT OR PREVENTION OF SYMPTOMS ASSOCIATED WITH ENDOCRINE DYSFUNCTION | EMORY UNIVERSITY (US) | 2013-05-16 | — | — | WO | disclosed |
| WO-2008112156-A1 | CHEMOKINE RECEPTOR MODULATORS | ALTIRIS THERAPEUTICS (US) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008109154-A1 | CHEMOKINE RECEPTOR MODULATORS | ALTIRIS THERAPEUTICS, INC. (US) | 2008-09-12 | — | — | WO | disclosed |