Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 9/20 | 0.56 |
| ▸ | CES1 | P23141 | 8/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL433480 | 0.81 | MAPT (0.56) | CES2CES1CYP2C19TSHRL3MBTL1 | |
| SCHEMBL147282 | 0.80 | CES2 (0.68) | CES2CES1CYP2C19TSHRL3MBTL1 | |
| SCHEMBL5073645 | 0.80 | CES2 (0.77) | CES2CES1CYP2C19TSHRL3MBTL1 | |
| SCHEMBL29664603 | 0.79 | CES2 (0.59) | CES2CES1CYP2C19TSHRL3MBTL1 | |
| Benzil SCHEMBL10610529 | 0.78 | CES2 (0.82) | CES2CES1CYP2C19TSHRL3MBTL1 | |
| Benzil SCHEMBL4125953 | 0.78 | CES2 (0.82) | CES2CES1CYP2C19TSHRL3MBTL1 | |
| SCHEMBL6207821 | 0.77 | CES2 (0.56) | CES2CES1CYP2C19TSHRL3MBTL1 | |
| SCHEMBL6427321 | 0.76 | CYP2C19 (0.64) | CES2CES1CYP2C19TSHRL3MBTL1 | |
| SCHEMBL10946651 | 0.75 | CES2 (0.68) | CES2CES1CYP2C19TSHRL3MBTL1 | |
| Benzil SCHEMBL2234045 | 0.75 | CES2 (0.88) | CES2CES1CYP2C19TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581496-A4 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1581496-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050613-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2004-06-17 | — | — | WO | disclosed |