Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | CRHBP | P24387 | 2/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL449144 | 0.78 | HTR2C (0.36) | ABCG2ITGB2ICAM1ITGALHTR2C | |
| SCHEMBL30563750 | 0.78 | HTR2C (0.36) | ABCG2ITGB2ICAM1ITGALHTR2C | |
| SCHEMBL23727987 | 0.64 | — | — | |
| SCHEMBL158578 | 0.64 | — | — | |
| SCHEMBL3074957 | 0.62 | ALOX5 (0.37) | ABCG2ITGB2ICAM1ITGALALOX5 | |
| SCHEMBL30484685 | 0.62 | — | — | |
| SCHEMBL186955 | 0.62 | — | — | |
| SCHEMBL3662203 | 0.60 | MAPT (0.37) | HTR2CHTR2BALOX5 | |
| SCHEMBL8924 | 0.60 | MAPT (0.37) | HTR2CHTR2BALOX5 | |
| SCHEMBL131072 | 0.60 | ITGB2 (0.52) | ABCG2ITGB2ICAM1ITGALLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3292104-A1 | CYCLOPROPANE CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Astrazeneca AB (SE) | 2018-03-14 | — | — | EP | disclosed |
| WO-2016177845-A1 | CYCLOPROPANE CARBOXYLIC ACID DERIVATIVES AND PHARMACEUTICAL USES THEREOF | ASTRAZENECA AB (SE) | 2016-11-10 | — | — | WO | disclosed |
| WO-2008099165-A1 | PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | WO | disclosed |