SCHEMBL449144

SCHEMBL449144

C1=Cc2ccccc2ONC1

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 1/20 0.36
HTR2B P41595 1/20 0.36
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32
KMT2A Q03164 1/20 0.32
ABCG2 Q9UNQ0 1/20 0.31
ITGB2 P05107 1/20 0.31
ICAM1 P05362 1/20 0.31
ITGAL P20701 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30563750 1.00 HTR2C (0.36) HTR2CHTR2BKDM4EMEN1ALDH1A1
SCHEMBL4744946 0.78 ABCG2 (0.33) HTR2CHTR2BABCG2ITGB2ICAM1
SCHEMBL9882907 0.76 ITGB2 (0.43) HTR2CHTR2BITGB2ICAM1ITGAL
Cycloheptane SCHEMBL29003966 0.68 CYP2B6 (0.41) HTR2CHTR2BKDM4EMEN1ALDH1A1
Cyclopentane SCHEMBL997321 0.68 CYP2B6 (0.41) HTR2CHTR2BKDM4EMEN1ALDH1A1
SCHEMBL2289180 0.67 CYP2B6 (0.43) HTR2CHTR2BKDM4EMEN1ALDH1A1
SCHEMBL9208 0.67 CYP2B6 (0.43) HTR2CHTR2BKDM4EMEN1ALDH1A1
SCHEMBL2281562 0.67 CYP2B6 (0.43) HTR2CHTR2BKDM4EMEN1ALDH1A1
SCHEMBL29364609 0.67 CYP2B6 (0.43) HTR2CHTR2BKDM4EMEN1ALDH1A1
SCHEMBL11135785 0.67 CYP2B6 (0.43) HTR2CHTR2BKDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 370 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113861128-A Polymerizable compound and optically anisotropic body 江苏创拓新材料有限公司 2021-12-31 CN claimed
EP-1852420-B1 Indole compounds for treating respiratory disorders ONO PHARMACEUTICAL CO (JP) 2012-10-17 EP claimed
US-8153625-B2 Nitrogen-containing heterocyclic compounds and medicinal use thereof ONO PHARMACEUTICAL CO., LTD. (JP) 2012-04-10 US claimed
US-7759336-B2 Nitrogen-containing heterocyclic compounds and medicinal use thereof ONO PHARMACEUTICAL CO., LTD. (JP) 2010-07-20 US claimed
US-12600730-B2 Substituted cyclopenta[c]pyrroles as ABHD6 antagonists ONO PHARMACEUTICAL CO., LTD. (JP) 2026-04-14 US disclosed
US-20260083735-A1 ABHD6 ANTAGONIST ONO PHARMACEUTICAL CO., LTD. (JP) 2026-03-26 US disclosed
CN-121586713-A Quinoline derivatives and pharmaceutical compositions thereof for the treatment of diseases 百济神州(苏州)生物科技有限公司 2026-02-27 CN disclosed
EP-4596555-A1 ABHD6 ANTAGONIST ONO Pharmaceutical Co., Ltd. (JP) 2025-08-06 EP disclosed
CN-114948963-B Benzolactam compounds as protein kinase inhibitors 大冢制药株式会社 2025-05-27 CN disclosed
CN-118984826-A Method for preparing compounds comprising 2, 5-dihydrobenzoxazepine structures by photochemical rearrangement 巴黎综合理工学院 2024-11-19 CN disclosed
CN-118984826-A Method for preparing compounds comprising 2, 5-dihydrobenzoxazepine structures by photochemical rearrangement 巴黎综合理工学院 2024-11-19 CN disclosed
CN-114605350-B Polymerizable compound, polymerizable composition containing same, and optically anisotropic body 江苏创拓新材料有限公司 2024-09-13 CN disclosed
WO-1996017833-A1 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1996-06-13 WO disclosed
EP-0593603-A1 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1994-04-27 EP disclosed
WO-1993000095-A2 BICYCLIC FIBRINOGEN ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1993-01-07 WO disclosed
US-5135927-A 2-chloro-4-trifluoromethylthiazol-5-carboxylic acid CIBA-GEIGY CORPORATION (US) 1992-08-04 US disclosed
US-4992434-A Prevention of infestation of plants by phytopathogenic microorganisms CIBA-GEIGY CORPORATION (US) 1991-02-12 US disclosed
US-4504663-A ANALGESIC, ANTIDEPRESSANT DELALANDE S.A. (FR) 1985-03-12 US disclosed
US-4431851-A ANALGESICS, ANTIDEPRESSANTS DELALANDE S.A. (FR) 1984-02-14 US disclosed
US-4386090-A ANALGESICS, ANTIDEPRESSANTS DELALANDE S.A. (FR) 1983-05-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12600730-B2 Substituted cyclopenta[c]pyrroles as ABHD6 antagonists ABHD6, ABHD16A, HDHD5 HTR2C 2994/4885HTR2B 4330/4885KDM4E 1505/4885
US-20260083735-A1 ABHD6 ANTAGONIST ABHD6, ABHD16A, ABHD12 HTR2C 2982/4885HTR2B 3780/4885KDM4E 2124/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.