Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.67 |
| ▸ | HRH2 | P25021 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746753 | 0.84 | KDM4E (0.52) | HRH3KDM4EKMT2AALDH1A1HRH4 | |
| SCHEMBL4746684 | 0.83 | HRH4 (0.55) | HRH3KDM4EALDH1A1HRH4 | |
| SCHEMBL27853347 | 0.82 | HRH3 (0.78) | HRH3HRH2HRH1KDM4ETDP1 | |
| SCHEMBL4814712 | 0.82 | KDM4E (0.50) | HRH3KDM4EALDH1A1 | |
| SCHEMBL20236140 | 0.81 | HRH3 (0.76) | HRH3HRH2HRH1KDM4ETDP1 | |
| SCHEMBL490968 | 0.81 | HRH3 (1.00) | HRH3KDM4ETDP1KMT2AALDH1A1 | |
| SCHEMBL5857282 | 0.80 | HRH3 (0.97) | HRH3KDM4ETDP1KMT2AALDH1A1 | |
| SCHEMBL4743300 | 0.79 | HRH3 (0.57) | HRH3HRH1KMT2AHRH4 | |
| SCHEMBL4746206 | 0.79 | HRH3 (0.57) | HRH3KMT2A | |
| SCHEMBL4746222 | 0.79 | HRH3 (0.54) | HRH3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107320-A1 | PIPERIDINE AND PIPERAZINE DERIVATIVES USED AS ANTI-NEOPLASIC AGENTS OR CELL PROLIFERATION INHIBITORS | CEREP (FR) | 2008-09-12 | — | — | WO | disclosed |