Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNPH1 | O43598 | 4/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.48 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.48 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.48 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.48 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7787281 | 0.92 | P2RX3 (0.49) | SRCP2RY2P2RY1SMN1; SMN2ALDH1A1 | |
| SCHEMBL887094 | 0.91 | P2RX3 (0.50) | SRCP2RY2P2RY1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20225051 | 0.88 | P2RY1 (0.62) | DNPH1TAS1R3TAS1R1PRKAB2TRPM2 | |
| SCHEMBL15713382 | 0.88 | DNPH1 (0.47) | DNPH1TAS1R3TAS1R1PRKAB2TRPM2 | |
| SCHEMBL285262 | 0.88 | P2RY1 (0.62) | DNPH1TAS1R3TAS1R1PRKAB2TRPM2 | |
| SCHEMBL20324734 | 0.88 | P2RY1 (0.47) | DNPH1TAS1R3TAS1R1PRKAB2TRPM2 | |
| SCHEMBL20225019 | 0.88 | P2RY1 (0.62) | DNPH1TAS1R3TAS1R1PRKAB2TRPM2 | |
| SCHEMBL18837728 | 0.88 | P2RY1 (0.62) | DNPH1TAS1R3TAS1R1PRKAB2TRPM2 | |
| SCHEMBL20959779 | 0.88 | P2RY1 (0.62) | DNPH1TAS1R3TAS1R1PRKAB2TRPM2 | |
| SCHEMBL24181937 | 0.85 | SMN1; SMN2 (0.45) | DNPH1TAS1R3TAS1R1PRKAB2TRPM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060105375-A1 | Bioretrosynthetic methods for preparing products and compositions related thereto | VANDERBILT UNIVERSITY | 2006-05-18 | — | — | US | claimed |
| WO-2006044918-A2 | COMPOUNDS USEFUL AS SUBSTRATES FOR ENZYMES THAT REVERSE NUCLEOTIDYLYLATED PEPTIDE AND PROTEIN MODIFICATIONS AND METHODS FOR PRODUCTION AND USES THEREOF | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2006-04-27 | — | — | WO | claimed |
| US-5756711-A | Phospholipid derivatives of nucleosides and their use as anti-viral medicaments | BOEHRINGER MANNHEIM GMBH (DE) | 1998-05-26 | — | — | US | claimed |
| EP-0545966-B1 | NEW PHOSPHOLIPID DERIVATIVES OF NUCLEOSIDES, THEIR PREPARATION AND THEIR USE AS ANTIVIRAL DRUGS | BOEHRINGER MANNHEIM GMBH (DE) | 1994-11-23 | — | — | EP | claimed |
| US-20210353760-A1 | PRO-CYCLIC DINUCLEOTIDES AND PRO-CYCLIC DINUCLEOTIDE CONJUGATES FOR CYTOKINE INDUCTION | INVIVOGEN (FR) | 2021-11-18 | — | — | US | disclosed |
| US-20080249066-A1 | ANTIVIRAL COMPOUNDS AND COMPOSITIONS | ARDEA BIOSCIENCES, INC. (US) | 2008-10-09 | — | — | US | disclosed |
| WO-2008118879-A2 | ANTIVIRAL COMPOSITIONS COMPRISING 2 COMPOUNDS | ARDEA BIOSCIENCES, INC. (US) | 2008-10-02 | — | — | WO | disclosed |
| US-20060105375-A1 | Bioretrosynthetic methods for preparing products and compositions related thereto | VANDERBILT UNIVERSITY | 2006-05-18 | — | — | US | disclosed |
| WO-2006044918-A2 | COMPOUNDS USEFUL AS SUBSTRATES FOR ENZYMES THAT REVERSE NUCLEOTIDYLYLATED PEPTIDE AND PROTEIN MODIFICATIONS AND METHODS FOR PRODUCTION AND USES THEREOF | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2006-04-27 | — | — | WO | disclosed |
| US-5756711-A | Phospholipid derivatives of nucleosides and their use as anti-viral medicaments | BOEHRINGER MANNHEIM GMBH (DE) | 1998-05-26 | — | — | US | disclosed |
| US-5563257-A | Phospholipid derivatives of nucleosides | BOEHRINGER MANNHEIM GMBH (DE) | 1996-10-08 | — | — | US | disclosed |
| EP-0355135-B1 | ADENOSINE DEAMINASE-STABLE ANTI-RETROVIRAL NUCLEOSIDES | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1993-08-04 | — | — | EP | disclosed |
| EP-0374096-B1 | COMBINATION THERAPY INVOLVING 2',3'-DIDEOXYPURINE NUCLEOSIDE AND AN INHIBITOR OF PURINE NUCLEOSIDE PHOSPHORYLASE, AND ITS COMPOSITIONS | CIBA-GEIGY AG (CH) | 1992-12-02 | — | — | EP | disclosed |
| EP-0509470-A2 | Therapeutical compositions having anti-HIV activity consisting of 2',3'-didesoxyadenosine and substances inhibiting adenosine deaminase | REPLA CHEMICAL LTD. (LI) | 1992-10-21 | — | — | EP | disclosed |
| EP-0374096-A1 | Combination therapy involving 2',3'-dideoxypurine nucleoside and an inhibitor of purine nucleoside phosphorylase, and its compositions | CIBA-GEIGY AG (CH) | 1990-06-20 | — | — | EP | disclosed |
| EP-0355135-A4 | ADENOSINE DEAMINASE-STABLE ANTI-RETROVIRAL NUCLEOSIDES. | SCRIPPS CLINIC RES (US) | 1990-04-09 | — | — | EP | disclosed |
| EP-0355135-A1 | ADENOSINE DEAMINASE-STABLE ANTI-RETROVIRAL NUCLEOSIDES | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1990-02-28 | — | — | EP | disclosed |
| WO-1989004662-A1 | ADENOSINE DEAMINASE-STABLE ANTI-RETROVIRAL NUCLEOSIDES | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1989-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249066-A1 | ANTIVIRAL COMPOUNDS AND COMPOSITIONS | PNP, TYMP, MTAP | DNPH1 1664/4885TAS1R3 4004/4885TAS1R1 3974/4885 |
| US-20210353760-A1 | PRO-CYCLIC DINUCLEOTIDES AND PRO-CYCLIC DINUCLEOTIDE CONJUGATES FOR CYTOKINE INDUCTION | STING1, CGAS, TLR9 | DNPH1 2014/4885TAS1R3 2434/4885TAS1R1 2294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.