Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.40 |
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.35 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 4/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748502 | 0.83 | IDO1 (0.41) | GRM5 | |
| SCHEMBL4745710 | 0.81 | KCNA5 (0.35) | AKR1B1AAK1KCNQ4KCNQ5RIPK3 | |
| SCHEMBL4745826 | 0.81 | KCNA5 (0.35) | AKR1B1AAK1KCNQ4KCNQ5PTGER1 | |
| SCHEMBL4749155 | 0.79 | AAK1 (0.36) | AAK1KCNQ4KCNQ5 | |
| SCHEMBL4749154 | 0.79 | AAK1 (0.36) | AAK1KCNQ4KCNQ5 | |
| SCHEMBL4518262 | 0.75 | AKR1B1 (0.45) | AKR1B1AKR1B10AKR1A1ACHE | |
| SCHEMBL4518252 | 0.74 | AKR1B1 (0.48) | AKR1B1GRM5AKR1B10AKR1A1PTGER1 | |
| SCHEMBL3750959 | 0.74 | RORC (0.37) | AAK1 | |
| SCHEMBL3750954 | 0.74 | RORC (0.37) | AAK1 | |
| SCHEMBL857284 | 0.69 | HTT (0.55) | KCNQ4KCNQ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124518-A1 | OXO-DIHYDROISOINDOLE SULFONAMIDE COMPOUNDS AS MODULATORS OF THE CCK2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-10-16 | — | — | WO | disclosed |